Postdoctoral Fellow - Cellular Neurophysiology or Integrative Neuroscience with Neural Circuit Studies Job at SRI International
Overview:
The Sleep Neurobiology Laboratory at SRI International, located in the beautiful San Francisco Bay Area adjacent to Silicon Valley, has an opening for a Postdoctoral Fellow with a background in cellular neurophysiology or integrative neuroscience and expertise in neural circuit studies. The Fellow will work with a team of Research Scientists and technical staff to investigate the properties of neuronal cell types involved in sleep/wake control, their interconnections, and their roles in the neural circuits underlying arousal state control and in the sleep disorder narcolepsy. Cortical nNOS/NK1 neurons (Williams et al., 2019, Cerebral Cortex 29:1090-1108), TAAR1 (Black et al., 2017, Biol Psychiatry 82:623-633), hypothalamic hypocretin/orexin and MCH neurons (Izawa et al., 2019, Science 365:1308-13) and the sleep disorder narcolepsy are of particular interest. Opportunities exist to collaborate with scientists involved in drug discovery.
Responsibilities:
Responsibilities of the position include:
Whole-cell brain slice electrophysiological recordings- Optogenetic, pharmacogenetic, neuroanatomical approaches for manipulation of neuronal activity
- In vivo recording of brain activity using electrophysiology, fiber photometry and/or microendoscopy
- Design, execute, and analyze experiments to investigate the function of specific cell types
- Work with others to develop a pipeline for large-scale, systematic characterization of the physiological and connectional properties of different neuronal cell types
- Work with others to develop paradigms to correlate physiological, morphological and molecular properties within a single neuron
- Seek and evaluate new cutting-edge technologies in related areas
- Publish/present findings in peer-reviewed journals/scientific conferences
- Present progress reports to fellow researchers in the laboratory and larger organization
There is a career path from Postdoctoral Fellow to Research Scientist at SRI. Appointment at either level confers eligibility for Principal Investigator privileges.
Qualifications:
- Postdoctoral Fellow: Ph.D. or M.D. in a life science or related discipline with minimum 0-3 years post-PhD experience
- (We will also consider candidates for Research Scientist: Ph.D. or M.D. in a life science or related discipline with >3 years post-PhD experience)
- Working experience in neurobiology research
- Experience in brain slice electrophysiology and synaptic physiology and/or
- Experience with use of viral vectors, stereotaxic surgery and optogenetics/chemogenetics/fiber photometry/ microendoscopy/neuroanatomy
- Strong data analysis skills and publication record
- Ability to meet aggressive timelines and deliverables
- Strong commitment to collaborative teamwork
- Excellent problem solving and experiment managing skills
Salary for this position will be between $64,400 and $72,000 depending on several factors, including market competitiveness and equity amongst internal employees in similar roles. SRI has a competitive benefits package, to view details please go to: https://www.sri.com/resources/benefits/. SRI International, an over 75-year strong pioneering research institute, has a rich history supporting government and industry. Our innovations have created new industries, billions of dollars in market value and lasting benefits to society. SRI is organized around broad disciplines and capabilities, with research and development divisions and labs to groups who excel at identifying new opportunities, developing products and creating custom solutions. Our organization is driven by impact - delivering unique solutions for the world's important challenges and transforming ideas into reality for clients and partners.
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