Job Description

At Gilead we believe every employee deserves a great leader. As a people leader now or in the future, we expect that you will model and create an environment of inclusion, be intentionally focused on the hiring, development, growth and retention of talent, and empower teams to align and achieve goals.

Job Description

Responsibilities (include but limited to):
Develop and optimize protocols for T cell gene editing, including; gene editing platform delivery methods, culture conditions to support platform build and therapeutic program development
Design and initiate development of assays to characterize genetically engineered and edited primary T cells to support early product characterization
Planning and hands-on execution of ex vivo and in vitro cellular assays, including significant flow cytometry analysis and downstream molecular biology
Develop and communicate experimental plans to demonstrate the efficacy of therapeutic product candidates
Perform data analysis and report results to scientific team and executive management
Work together with project leaders, research department, and other groups across Kite to drive project success
Exercise independent judgment in development of new methods, techniques and evaluation criteria
Lead, train and mentor junior staff
Help author technical reports and CMC sections of IND submissions
Execute laboratory studies to support vector and T-cell process development and characterization
Write and review technical documentation around viral vector processes
Other duties as assigned

Requirements:
PhD in Immunology, Cell Biology, Bioengineering, or a related discipline. Post-doctoral experience welcome but not required. Industry experience preferred but not required. 7+ years of relevant experience with Bachelors degree.
Solid understanding of immunology, including familiarity with T cell development and function, immune receptor signaling and the biology of chimeric antigen receptors
Applied experience in gene-edited T cell therapies
Expertise in Process development and GMP clinical manufacturing of cell therapy products is a plus
Expertise with in vitro models of cancer and cellular immunotherapy, including immunological assays to assess T cell function (in vitro cell proliferation assays, T cell activation/cytotoxic killing assays, cytokine profiling and/or immune cell isolation)
Familiarity with gene editing technique and applications, including ZFNs, CRISPR and/or use of AAV- and lentiviral vectors is preferred
Strong technical background with standard laboratory methods, including: polychromatic flow cytometry; molecular biology and cloning; virus handling; PCR; ELISA; intracellular staining;
Ability to work effectively in a collaborative team environment where results are achieved through influence, cooperation, and the incorporation of multiple points of view
Independently motivated, detail oriented and good problem solving ability
Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment
Motivated and curious, experienced working with highly technical projects and personnel
Highly adaptable and responsive to technical and business opportunities, comfortable delivering against challenging commitments

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

• Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For jobs in France:

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