Alpine Immune Sciences is applying our platform discovery technology to bring innovative new therapies to people living with serious or life-threatening illnesses or conditions, such as cancer and autoimmune/inflammatory diseases. Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges. Join us!

This individual will support pre-clinical development of new or emerging candidate therapies in our pipeline that modulate the immune system for the treatment of cancer and/or autoimmune disorders. This individual will develop and execute on workplans to advance candidate drugs from preclinical discovery into early clinical development in a team-oriented environment.

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Key Responsibilities*

• Experiment design, execution, data analysis, interpretation, communication and documentation of results
• Cell-based immune assays focused on characterizing therapeutics that modulate immune cells

o T-cell proliferation/activation
o Cytotoxicity and cytokine induction
o Multi-parameter flow cytometry
o Experience with innate and adaptive immune signaling

• Participate in matrixed project teams, with the opportunity to lead future early stage projects, which includes collaborating cross-functionally with protein engineering, in vivo pharmacology and translational medicine colleagues to advance therapeutic candidates
• Apply expertise in immunology, cell/cancer biology and drug discovery to progress project though development milestones
• Interact with external groups, such as contract research organizations and collaborators, to commission work or transfer assays as needed
• Author or contribute to pre-clinical technical reports supporting regulatory filings (IND/CTDs, NDA/BLA, DSUR etc.) and abstracts/manuscripts for publication

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Required Qualifications*

• PhD, or MS with at least 2 additional years of lab experience, or Bachelor’s with at least 5 additional years of lab experience, in immunology, immuno-oncology, cancer research, cell biology, pharmacology/drug discovery; as evidenced by high impact peer-reviewed publications and /or a strong track record in pharmaceutical drug development
• Experience developing and executing cell-based assays, preferably with protein based biologic candidates across a broad array of therapeutic classes
• Knowledge of cancer/immunology molecular targets, a proven track record of assay development and knowledge of relevant preclinical cancer and autoimmune models
• Decisive results-oriented individual who is flexible, team-oriented, creative and able to excel in a multi-project, fast-track environment
• Excellent communication, interpersonal skills and proven ability to collaborate across multidisciplinary scientific settings
• Strategic thinker who interacts and collaborates with project teams, peers and management in achieving discovery goals from both scientific and strategic perspectives
• Experience in authoring technical documents

#LI-Onsite

Alpinists share a passion for meaningful work and are committed to solving the most complex problems in immunology to create new therapies for patients. We believe in innovative thinking, collaboration, flexibility, bias for action, and healthy debate. To foster our team of outstanding scientists and business professionals, we provide a premier work environment with a state-of-the-art lab and office spaces with truly inspiring views, and an open design to facilitate teamwork.

Our treasured culture has been shaped by our diverse team who truly enjoys working and playing together. We nurture Alpine’s culture in many ways, including all-company social events and happy hours, lunch-and-learn and education opportunities, interest groups like book club and movie nights, peer-to-peer recognition programs, a robust wellness program to help support physical, mental, and emotional health, and more.

We take care of our employees with competitive benefits package which includes premium medical, dental, and vision coverage for employees and their dependents, wellness programs, FSA and 401(k) plans. We believe that quality time outside the office is vital to our employees’ satisfaction at work. That’s why our flexible PTO plan encourages team members to take time off so they can come back refreshed. Alpine team members enjoy competitive salaries and equity participation (stock options).

Alpine is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status. Alpine is also committed to compliance with all fair employment practices regarding citizenship and immigration status.

As a condition of employment, Alpine requires that employees are up to date with COVID-19 vaccination. In order to be considered up to date, employees must have completed a primary series of a SARS-CoV-2 vaccine, followed by a booster dose, as recommended by the CDC. Employees can submit requests for medical or religious exemption so that Alpine can consider possible accommodations.

Our office and lab are located in the blossoming biotech neighborhood of Eastlake in Seattle. Alpinists enjoy the flexibility to work onsite, remotely, or a hybrid schedule, with evolving options as we prioritize keeping Alpinists safe and healthy during the COVID pandemic. Onsite employees enjoy an open-office layout with comfortable huddle rooms and Zoom Room-enabled conference rooms, a spacious breakroom and kitchen with a coffee bar and snacks, and rooftop access to enjoy gorgeous views of Lake Union and Gas Works Park.

Exciting challenges lie ahead—guided by our core values, we’ll meet these challenges. Join us!

Job Type: Full-time

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