About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to addressing the underlying cause of severe diseases by upregulating protein expression with RNA-based medicines. Using the company’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore protein levels. Stoke’s first compound, STK-001 is in clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. Dravet syndrome is one of many diseases caused by a haploinsufficiency, in which a loss of ~50% of normal protein levels leads to disease. Stoke is pursuing the development of STK-002 for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. Stoke’s initial focus is haploinsufficiencies and diseases of the central nervous system and the eye, although proof of concept has been demonstrated in other organs, tissues, and systems, supporting the company’s belief in the broad potential for its proprietary approach. Stoke is headquartered in Bedford, Massachusetts with offices in Cambridge, Massachusetts.

Position Purpose:

The R&D Systems Manager is responsible for computer systems and applications in the laboratory. Additionally, the role will be charged with leading the development and support of R&D laboratory automation capabilities. Leveraging expertise in crucial instrumentation and scientific principles, the R&D Systems Manager will outline, evaluate, and implement efficient methodologies ensuring interconnectivity of instrument arrays, ancillary equipment, and corresponding controlling software packages. This role reports to the Head of IT at Stoke and will work closely and coordinate activities with scientists, vendor personnel, and other IT functions in a collaborative setting to support effective automated laboratory workflows.

Key Responsibilities:

• Design, build, and optimize lab systems integration and automation so data is centrally stored, processed, and analyzed.
• Maintain data integrity and accuracy.
• Provide technical support to internal customers in the use of laboratory systems and tools.
• Using requirements sourced from stakeholders, develop and execute technical implementation plans to provide new and/or improved lab systems that support lab processes and functionalities.
• Continuously analyze processes, systems, and applications and recommend changes that improve lab operational efficiencies, security, and data organization and integrity.
• Provide technical support to internal customers in the use of laboratory systems and tools.

Required Skills & Experience:

• B.S. in computer science or B.S. biological/chemical sciences with minor in computer science.
• Minimum of 5 to 7 years biopharmaceutical industry experience, managing and building integrated lab automation systems a plus.
• Demonstrated experience developing and implementing automated laboratory processes.
• Experience developing and standardizing assays, methods, & other workflows in various instrumentation software and applications.
• Prior experience with data pipelining, transformation, and standardization.
• Experience with integration between instruments and other platforms like ELN, LIMS, SDMS, CDS, and visualization tools required.

• Strong knowledge in the interfacing of SDMS, CDS, LIMS, ELN, Sample Preparation Solutions, and individual Instrument Arrays components preferred.

• Experience with LabVantage LIMS, Perkin Elmer Signals, Waters Empower a plus.

• Experience in process automation and associated software and techniques.

• Experience with core IT concepts and functions a plus – RBAC and ACLs, SAML, networking, etc.
• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.
• A strong customer focus and ability to prioritize and adapt to changing business needs are required and ability to work independently and collaboratively in cross-functional teams.
• Excellent written and verbal communication skills including the ability to communicate and negotiate across the organization.
• Ability and willingness to both "roll up sleeves" and think strategically related to future growth and expansion.

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Culture & Values:

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do.

To protect the health and well-being of our team, company policy requires that all employees and all new hires be fully vaccinated against COVID-19. By applying, you are confirming that, if hired, you can satisfy this express condition of employment. We will make reasonable accommodations available as may be required by applicable law. We will continue to evaluate our practices as we move forward.

Location(s):

Stoke operates sites in Bedford, MA, and Cambridge, MA. This position is based in our Bedford, MA location.

Travel:

This position will require approximately 5% travel.

Benefits & Compensation:

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

https://www.stoketherapeutics.com/careers/

For more information, visit https://www.stoketherapeutics.com/ or follow the company on Twitter at @StokeTx.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.